Animal models for SARS and MERS coronaviruses
Identifieur interne : 001368 ( Main/Exploration ); précédent : 001367; suivant : 001369Animal models for SARS and MERS coronaviruses
Auteurs : Lisa M. Gretebeck ; Kanta SubbaraoSource :
- Current Opinion in Virology [ 1879-6257 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans.
Abstract
Animal coronaviruses can cause severe respiratory illness and death in humans. Coronavirus vaccines and antiviral drugs are not yet available. Animal models are needed to study pathogenesis and evaluate vaccines and antivirals. No single animal model can be used to study both SARS and MERS coronaviruses. The most appropriate animal model should be selected to meet experimental goals.
Url:
DOI: 10.1016/j.coviro.2015.06.009
PubMed: 26184451
PubMed Central: 4550498
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Animal models for SARS and MERS coronaviruses</title><author><name sortKey="Gretebeck, Lisa M" sort="Gretebeck, Lisa M" uniqKey="Gretebeck L" first="Lisa M" last="Gretebeck">Lisa M. Gretebeck</name></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26184451</idno><idno type="pmc">4550498</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550498</idno><idno type="RBID">PMC:4550498</idno><idno type="doi">10.1016/j.coviro.2015.06.009</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001734</idno><idno type="wicri:Area/Pmc/Curation">001734</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001734</idno><idno type="wicri:Area/Pmc/Checkpoint">000827</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000827</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:26184451</idno><idno type="wicri:Area/PubMed/Corpus">000D98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D98</idno><idno type="wicri:Area/PubMed/Curation">000D98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D98</idno><idno type="wicri:Area/PubMed/Checkpoint">000E60</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E60</idno><idno type="wicri:Area/Ncbi/Merge">002A99</idno><idno type="wicri:Area/Ncbi/Curation">002A99</idno><idno type="wicri:Area/Ncbi/Checkpoint">002A99</idno><idno type="wicri:doubleKey">1879-6257:2015:Gretebeck L:animal:models:for</idno><idno type="wicri:Area/Main/Merge">001370</idno><idno type="wicri:Area/Main/Curation">001368</idno><idno type="wicri:Area/Main/Exploration">001368</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Animal models for SARS and MERS coronaviruses</title><author><name sortKey="Gretebeck, Lisa M" sort="Gretebeck, Lisa M" uniqKey="Gretebeck L" first="Lisa M" last="Gretebeck">Lisa M. Gretebeck</name></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>SARS Virus (genetics)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Modèles animaux de maladie humaine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Animal coronaviruses can cause severe respiratory illness and death in humans.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Coronavirus vaccines and antiviral drugs are not yet available.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Animal models are needed to study pathogenesis and evaluate vaccines and antivirals.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">No single animal model can be used to study both SARS and MERS coronaviruses.</p></list-item><list-item id="lsti0025"><label>•</label><p id="par0025">The most appropriate animal model should be selected to meet experimental goals.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Masters, P S" uniqKey="Masters P">P.S. 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